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Circulation, stroke, heart attack, spinal cord injury, and traumatic brain injury may soon be amenable to LLLT (Boston Massachusetts General Hospital Photomedical Wellman Center Nov. 2nd, 2011)
Currently around 5,000 papers regarding LLLT called photobiomodulation have been published. From these papers, outstanding papers have been reported on the American national institute of health, national medical library (National Center for Biotechnology Information website – NCBI) Click the link below to see the appropriate research at the NIH website. On the menu on the right of this website, you can read research papers that are similar to the mentioned above.
Light therapy can directly damage tumor and enhance other cancer treatment… (Boston Massachusetts General Hospital Photomedical Wellman Center, 2018 May 1st)
Belgium Martelarenlaan Hasselt University, 2018 Feb 10th)
Oral mucositis is a common and repetitive severe side effect of head and neck cancer treatment. Using LLLT Photobiomodulation, it is found that it has effect on oral mucositis
Newly arising cost-effective treatment option for cancer (solid tumor)
Photobiomodulation has been arising as an effective mean to treat inflammatory diseases in ascites (ex. Oral Mucositis) in cancer patients undergoing radiation or chemotherapy
Chemotherapy-induced CIPN is a common disease caused from chemotherapy….(Texas university MD Anderson Cancer Center, Huston medical unit, 2018 Nov;21(6))
Belgium University of Liege Medical school, Dentistry, 2018 Dec. 6th
(Brazil, San Paulo Health Science, 2019 April, vol. 34)
(Photobiomodulation or low-level laser therapy)
USA New York Rochester university, medical center Eastman dental center 2018, May 22nd)
Brazil Rio de Janeiro R. Andre Cavalcanti clinical research national research institute of science, 2018, Jan, vol 33
Photobiomodulation enhances radiation sensitivity by causing apoptosis of cervical cancer cells
Photobiomodulation enhances radiation sensitivity by causing apoptosis of cervical cancer cells
Breast cancer related lymphedema (BCRL) is a prevalent complication secondary to cancer treatments which significantly impacts the physical and psychological health of breast cancer survivors. (New Zealand Dunedin University of Otago, National Rehabilitation Center, 2017 December 7th)
Boston Massachusetts General Hospital Photomedical Wellman Center 2017 June 6t
Germany Hamburg
Belgium Martelarenlaan Hasselt University Life Science Department, 2016 Aug 19th
Chinese Nanjing university medical school cancer research center, clinical tumor research center, 2017 Dec 26th
(Germany Offenbach Starkenburg Radiation tumor department 2017 june)
New Zealand Dunedin University of Otago Medical school, 2018 May 30th
Click the link below to see the appropriate research at the NIH website. On the menu on the right of this website, you can read research papers that are similar to the mentioned above.
Among patients with CIPN, PBM produced significant reduction in neuropathy symptoms. (University of Minnesota Division of Gynecologic Oncology, Department of women’s health)
LLLT is a viable phototherapeutic modality for the treatment of peripheral nerve injury, demonstrating positive effects on the neuromuscular repair process using either red or infrared light (Biophontonics graduate study program, Brazil Julho (UNINOVE) 2017.10)
49 consecutive subjects with established diabetic peripheral neuropathy were treated with monochromatic near-infrared photo energy (MIRE), which demonstrated 98% treatment effect (The Medical Center of Aurora, Aurora, CO, USA, 2002 March, vol. 92)
Improved foot sensitivity and reduced incidence of new diabetic foot wounds. (Northwest Orthopedic Center, Springdale, AR, USA, 2004 July 1st)
To determine whether treatments with the ATS would decrease pain and/or improve sensation diminished due to DPN under a sham-controlled, double-blind protocol (Joslin Center for Diabetes, Morton Plant Mease Healthcare, Clearwater, Florida 33756, USA, 2004 Jan 27th)
Pulsed infrared light therapy (PILT) has been shown to increase peripheral sensation in diabetic patients with diabetic peripheral neuropathy (DPN) (Physical Therapy Department, East Tennessee State University, 70624, Johnson City, TN 37614, USA, 2006 May, Vol. 4)
(Northwest Orthopedic Center, Springdale, AR 72764, USA, 2006 Jan 1st)
(Case Western Reserve University, Cleveland, Ohio state Medical studies. 2018 Feb)
Analyzing the gene expression of inflammatory/reparative factors (Biological and Health Sciences, 2018 Jan)
Innovative treatment options currently available in the treatment of non-healing DFUs (Professor and Associate Dean, Department of Physiotherapy, School of Allied Health Sciences 2018.12)
(2018 April Laser Research Centre, Faculty of Health Sciences, University of Johannesburg)
Currently around 5,000 papers regarding LLLT called photobiomodulation have been published. From these papers, outstanding papers have been reported on the American national institute of health, national medical library (National Center for Biotechnology Information website – NCBI).
Click the link below to see the appropriate research at the NIH website. On the menu on the right of this website, you can read research papers that are similar to the mentioned above.
Click the link below to see the appropriate research at the NIH website. On the menu on the right of this website, you can read research papers that are similar to the mentioned above.
The IR therapy unit used was demonstrated to be effective in reducing chronic low back pain, and no adverse effects were observed. (George D Gale, Rothbart centre for pain care, North York, USA)
All but one patient, including the authors, responded rapidly and significantly to the near-IR in one or two treatments without any adverse effects observed. (2012 May Everett Marc Lautin, MD, Radiology professor at Albert Einstein College of Medicine)
Acute orthopedic conditions such as sprains, strains, muscular back pain, cervical or lumbar radiculopathy, tendinitis and chronic conditions such as osteoarthritis, rheumatoid arthritis, frozen shoulder, neck and back pain, epicondylitis, carpal tunnel syndrome, tendinopathy, fibromyalgia, plantar fasciitis, and chronic regional pain syndrome are amenable to LLLT (2015 June, James Carroll, Dermatology at Harvard University,
(2015. 2. Panhoca, Sao Carlos Physics research (IFSC), University of San Paulo, Brazil)
Suggests that LLLT effectively relieves pain and improves functional outcomes in patients with TMD. TMD is treated more effectively with LLLT than drug therapy.
(2019 March. Bicknell B Australian Catholic University, North Sydney, Health Sciences)
(2018 Dec. Johnson DS. Multi Radiance Medical, Solon, Ohio)
(2019 March, Isu Kura H, Japan, Tokyo University, Rehabilitation medicine)
(2014 Dec Nakamura T. Tokyo University Medical school rehabilitation medicine)
(2016.9. Holanda VM San Paulo university school of medicine)
(2010.8 Konstantinovic LM)
Currently around 5,000 papers regarding LLLT called photobiomodulation have been published. From these papers, outstanding papers have been reported on the American national institute of health, national medical library (National Center for Biotechnology Information website – NCBI).
Click the link below to see the appropriate research at the NIH website. On the menu on the right of this website, you can read research papers that are similar to the mentioned above.
Click the link below to see the appropriate research at the NIH website. On the menu on the right of this website, you can read research papers that are similar to the mentioned above.
P.I. Quietmind Foundation, 1016 Greenwood Ave, Wyncote PA 19095, USA, 2017 Feb 28t
(REGEnLIFE, Montpellier, France, Amylgen, Montferrier-sur-Lez, France, 2018 Feb 2nd)
There is an evidence that Photobiomodultion (PBM) has positive effect on the brain. (Boston Massachusetts General HospitalWellman Center Dec 6th 2016)
Transcranial photobiomodulation is a potential innovative noninvasive therapeutic approach for improving brain bioenergetics, brain function in a wide range of neurological and psychiatric disorders, and memory enhancement in age-related cognitive decline and neurodegenerative diseases.
(Austrailia, Newsouthwales Sydney University Bosch Institute 2018 Jan 31st)
Near-infrared wavelengths (800-900 nm) and red (600 nm) light-emitting diodes (LED) are able to penetrate through the scalp and skull and have the potential to improve the subnormal cellular activity of compromised brain tissue (Brazil San Paulo Medical school neurosurgical department, 2018 April 24th)
(Boston Massachusetts, VA Boston medical system, 2016 Dec 1st
Brain damage, such as Traumatic Brain Injury (TBI) treatment including Low-Level Laser Therapy (LLLT) or PBM (Photobiomodulation)
Parkinsonian (MPTP) insult and/or photobiomodulation (670 nm) had any impact on encephalopsin expression in this key area… (Department of Anatomy F13, University of Sydney, Sydney, 2006, Australia, 2018 Jan 29th)
University of Grenoble Alpes, CEA, LETI, CLINATEX, MINATEC Campus, 38000, 2017 Oct)
Suggest that the applications of LLLT are much broader than at first conceived (Briarcliiff High school, Briarcliff Manor, NY, USA, 2016 Dec 14th)
(Wellman Center for photomedicine, Massachusetts General Hospital, Boston, MA, 2017 Nov, 13th)
PBM treatment helps
There is also much research going on to PMB treat stroke, depression, dementia, and Parkinson’s
These findings provide strong support for the promising therapeutic effect of PBM on neuronal repair following ischemic stroke. (Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA 2017 Oct 19th)
(McLean Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, 2017 August 1st)
Combined treatment strategies based on magnetic nanoparticles (MNPs) with near infrared ray (NIR) biophotonic possess tremendous potential (Medicine, Florida International University, Miami, Florida, 33199, USA, 2016 July 28th)
In the research, controlled group with traumatic brain injury (TBI) gave a significant improvement in neurological/cognitive function (Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA, 2016 March 15th)
After 1 week of PBM treatment, TBI patients showed 1 hour of increased sleep. (VA Boston Healthcare System, Boston, Massachusetts, 2015 September 1st)
(Department of psychology and institute for Neuroscience, University of Texas at Austin, Austin, TX, 78712, USA, 2017 May 2nd)
Application of red/NIR light improves mitochondrial function (especially in hypoxic/compromised cells) promoting increased adenosine triphosphate (ATP) important for cellular metabolism. Nitric oxide is released locally, increasing regional cerebral blood flow. Participants reported improved sleep, and fewer post-traumatic stress disorder (PTSD) symptoms, if present. (VA, Boston Healthcare System, Boston, Massachusetts, 2014 June 1st)
PBM shown to improve locomotor activity and to neuroprotect midbrain dopaminergic cells in rodent and monkey models of Parkinson’s disease (Department of Anatomy F13, University of Sydney, Sydney, 2006, Austrailia, 2017 March 15th)
The use of PBM significantly reduced the presence of Aβ plaques and improved spatial memory and behavioral and motor skills in treated animals on day 21.
Although laser therapy on human tissue has been used since the late 1960s, it is only recently that several clinical studies have shown its value in raising neurometabolic energy levels that can improve cerebral hemodynamics and cognitive abilities in humans.
Result of NIr treatment showed that MPTP induced Astrogliosis have significantly decreased (Department of Anatomy, F13, University of Sydney, Sydney, 2006, Austrailia, 2016 July 5th)
(Department of Anatomy F13, University of Sydney, Sydney, 2006, Australia, 2016년 7월 5일)
Cardiovascular and cerebrovascular diseases are major risk factors in the development of cognitive impairment and Alzheimer’s disease (AD). These cardio-cerebral disorders promote a variety of vascular risk factors which in the presence of advancing age are prone to markedly reduce cerebral perfusion and create a neuronal energy crisis (Departmnet of psychology, University of Texas at Austin, Austin, TX, 2016 June 20th)
The results showed that behavioral problems decreased regardless of the timing of root treatment (CLINATEC, EJ Safra Centre, CEA, LETI, University of Grenoble Alpes, 38000, Grenoble, France, 2016)
Postoperative cognitive dysfunction (POCD) is a decline in memory following anaesthesia and surgery in elderly patients. Photobiomodulation (PBM) is an effective treatment for a number of conditions, including inflammation (University of Sydney, Sydney, NSW Austrailia, 2016 Jan 11th)
“Here we propose NIr therapy as a neuroprotective or disease-modifying treatment for Alzheimer’s and Parkinson’s patients (Department of Physiology, University of Sydney, Sydney, NSW Australia, 2016 Oct 19th)
Photobiomodulation effects of the low-energy laser and LED radiation is also considered as a potential tool for the rehabilitation of patients with various pathologies, yielding positive results in both PD and AD. (MedlinePlus Trusted Health Information for you, 2016 vol.96)
Deliver near-infrared light (NIr) to the midbrain of 6-hydroxydopamine (6-OHDA)-lesioned rats, a model of Parkinson’s disease (CEA, Leti, and Clinatec Departments, University Grenoble Alpes, Minatec Campus, Grenoble, France; 2015 Nov 27th)
(Centre de Recherche du Centre Hospitalier de Québec, Axe Neuroscience et Département de Médecine Moléculaire de l’Université Laval, Québec, G1V4G2, Canada, 2015 Oct 20th)
(Photobiomodulation (PBM) appears promising to treat the hallmarks of Parkinson’s Disease (PD) in cellular or animal models (Federal Institute of Technology (EPFL), Institute of Chemical Sciences and Engineering (ISIC), 1015 Lausanne, Switzerland, 2015, March 19th)
Photobiomodulation (PBM) also known as low-level light therapy (LLLT) has been used successfully for the treatment of injury and disease of the nervous system. (LumiThera, Inc., Poulsbo, Washington, 98370, 2015 March 13th)
Our results, in two transgenic mouse models, suggest that NIr may have potential as an effective, minimally-invasive intervention for mitigating, and even reversing, progressive cerebral degenerations (University of Sydney NSW 2006, Austrailia, 2014 Jan 3rd)
Improving brain mitochondrial respiration is an important future direction in research and treatment of Alzheimer’s disease (AD) and other conditions associated with cognitive impairment and neurodegeneration. (USA; Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA, 2014 April 15th)
(CEA-Leti, Grenoble, France; and, 2013 Oct 25th)
NIr treatment saves dopaminergic cells in the parkinsonian condition (Discipline of Physiology, University of Sydney, Australia; Bosch Institute, University of Sydney, Australia, 2013)
Stimulation of lateral brain using red NIr light leads to transforming biological function or uses a non-destructive method to induce neurological treatment effect.
(CEA, LETI, CLINATEC, Grenoble 38054, France, 2013 March 27th)
(Cardiothoracic Surgery Department, Easton Hospital, Easton, Pennsylvania, USA, 2012 Sept 11th)
(Department of Neurology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, 2012 July 13th)
(Department of Health Sciences, College of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States of America, 2012 Jan 24th)
(Discipline of Anatomy & Histology F13, University of Sydney, Australia, 2012 Jan 28th)
Department of Psychology, Pharmacology and Toxicology, University of Texas at Austin, Austin, TX, 2011 Oct 14th)
It is shown that LPLI decreases Aβ induced apoptosis
Currently around 5,000 papers regarding LLLT called photobiomodulation have been published. From these papers, outstanding papers have been reported on the American national institute of health, national medical library (National Center for Biotechnology Information website – NCBI).
Click the link below to see the appropriate research at the NIH website. On the menu on the right of this website, you can read research papers that are similar to the mentioned above.
Click the link below to see the appropriate research at the NIH website. On the menu on the right of this website, you can read research papers that are similar to the mentioned above.
Department of Health Sciences, College of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States of America.2012.7
(Photomedicine, Massachusetts general hospital, BAR414, 40 Flower street, Boston, MA 02114 Wellman center, Harvard Medical School, department of Dermatology, Boston, MA 02115, USA)
( Authors: Janis T. Eells, Kristina D. DeSmet, Diana K. Kirk, Margaret Wong-Riley, Harry T. Whelan, James Ver Hoeve)
(Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical school Dermatology, Boston, 02114, MA, USA, 2018 Jan.)
Effect of 670nm light treatment on nitrosative stress (Wisconsin, Milwaukee – Milwaukee University medical school life science 2013 June)
(Nove de Julho University (UNINOVE). University Metropolitana de Santos (UNIMES) 2018. May)
(Jeri-Anne Lyons, University of Wisconsin-Milwaukee, Wisconsin, 2015 April)
Currently around 5,000 papers regarding LLLT called photobiomodulation have been published. From these papers, outstanding papers have been reported on the American national institute of health, national medical library (National Center for Biotechnology Information website – NCBI).
Click the link below to see the appropriate research at the NIH website. On the menu on the right of this website, you can read research papers that are similar to the mentioned above.
Click the link below to see the appropriate research at the NIH website. On the menu on the right of this website, you can read research papers that are similar to the mentioned above.
PBM can increase muscle mass gained after training, and decrease inflammation and oxidative stress in muscle biopsies (2016 12 Hamblin MR Massachusetts General Hospital)
(2017 Nov. Leal-Junior ECP Norway Bergen University School of Medicine)
Low-level laser therapy increases antioxidant activity
(Department of Physiotherapy and Physiology, Universidade Luterana do Brasil, Brazil. 2006 8)
(Georgia Southern University, Statesboro, Georgia, Kinesiology)
On isokinetic muscleperformance of young women submitted to endurance training: a randomized controlled clinical trial
(Latin America Life Science research institute)
(2016 Oct AA Brazil University of Sao Paulo)
(2015 Nov, Fernandes KR Universidade Federal de Sao Paulo University of Sao Paulo)
(2016 March, Foley J: Lehigh University, Bethlehem, USA, Lehigh University Sports Medicine Department)
(Latin America Life Science research institute)
Currently around 5,000 papers regarding LLLT called photobiomodulation have been published. From these papers, outstanding papers have been reported on the American national institute of health, national medical library (National Center for Biotechnology Information website – NCBI).
Click the link below to see the appropriate research at the NIH website. On the menu on the right of this website, you can read research papers that are similar to the mentioned above.
Click the link below to see the appropriate research at the NIH website. On the menu on the right of this website, you can read research papers that are similar to the mentioned above.
B A Russell , N Kellett, L R Reilly, J Cosmet Laser Ther. 2005 Dec
Jared Jagdeo, Evan Austin , Andrew Mamalis, Christopher Wong, Derek Ho, Daniel M Siegel, Lasers Surg Med. 2018 Jan 22
A review of the clinical literature pertaining to the use of LLLT for skin rejuvenation, Aesthet Surg J. 2022 Apr 12
Tamara W Griffiths, Rachel E B Watson, Abigail K Langton, Br J Dermatol, 2023 Oct 30
Y Fukui, A De Lozanne, J A Spudich, J Cell Biol, 1990 Feb
Maria Luisa Hernández-Bule, Jorge Naharro-Rodríguez, Stefano Bacci, Montserrat Fernández-Guarino, Int J Mol Sci, 2024 Apr 19
Jessica Mineroff, Jalal Maghfour, David M Ozog, Henry W Lim, Indermeet Kohli, Jared Jagdeo, J Am Acad Dermatol, 2024 Nov
Annelie H Musters, Soudeh Mashayekhi, Jane Harvey, Emma Axon, Stephanie J Lax, Carsten Flohr, Aaron M Drucker, Cochrane Database Syst Rev, 2021 Oct 28
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